We have been playing around with the MSI 270 and ASUS Z270F motherboards for crypto mining with support of up to 7 GPUs . So far we have tried running the motherboards with thirteen Nvidia ( 6 GPU Zotac 1060 6GB G-FORCE NVIDIA connected with MSI Z270 and 7 GPU Nvidia MINI 1060 6GB G-FORCE NVIDIA GPUs – CONNECTED WITH ASUS Z 270 F GeForce GTX 1060 under Windows 10.